Technology Process of (2-(6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)ethyl)phosphonic acid
There total 9 articles about (2-(6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)ethyl)phosphonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanol; trimethylsilyl bromide;
In
dichloromethane;
at 20 ℃;
for 72h;
DOI:10.1021/jm500629e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,6-dimethylpyridine; osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; toluene / 2 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
2.2: 1 h / 20 °C
3.1: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 20 °C
4.1: trimethylsilyl bromide; methanol / dichloromethane / 72 h / 20 °C
With
2,6-dimethylpyridine; methanol; osmium(VIII) oxide; trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; sodium hydride; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/jm500629e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 20 °C
2: trimethylsilyl bromide; methanol / dichloromethane / 72 h / 20 °C
With
methanol; trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen;
In
ethanol; dichloromethane;
DOI:10.1021/jm500629e
