1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone

Base Information

• Chemical Name: 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone
• CAS No.: 1392282-83-5
• Molecular Formula: C₁₉H₁₉NO
• Molecular Weight: 277.366
• Mol file: 1392282-83-5.mol

Synonyms:1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone

Chemical Property of 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone

There total 2 articles about 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

diphenylacetic acid chloride (1871-76-7) + 3-methyl-1-[(4-methylphenyl)-sulfonyl]-2,5-dihydro-1H-pyrrole (160750-61-8) → 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone (1392282-83-5)

Guidance literature:

3-methyl-1-[(4-methylphenyl)-sulfonyl]-2,5-dihydro-1H-pyrrole; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

diphenylacetic acid chloride; With triethylamine; In diethyl ether; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201104073

Reference yield:

N-allyl-4-methyl-N-(2-methylallyl)benzenesulfonamide (594858-64-7) → 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone (1392282-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane

2.1: Na-naphthalenide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201104073

Reference yield: 100.0%

1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone (1392282-83-5) → 1-(3-methylpyrrolidin-1-yl)-2,2-diphenylethanone (1392282-89-1,1392283-29-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 1500.15 Torr;

DOI:10.1002/chem.201104073

upstream raw materials:

diphenylacetic acid chloride

3-methyl-1-[(4-methylphenyl)-sulfonyl]-2,5-dihydro-1H-pyrrole

N-allyl-4-methyl-N-(2-methylallyl)benzenesulfonamide

Downstream raw materials:

1-(3-methylpyrrolidin-1-yl)-2,2-diphenylethanone