594858-64-7

Upstream product

• 1206-41-3 N-(2-methylallyl)-4-toluenesulfonamide 
• 106-95-6 allyl bromide 
• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 563-47-3 3-Chloro-2-methylpropene 
• 98-59-9 p-toluenesulfonyl chloride 
• 6728-21-8 allyl mesylate 
• 70-55-3 toluene-4-sulfonamide 
• 462996-06-1 N-allyl-N-tert-butoxycarbonyl-p-toluenesulfonamide 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 1458-98-6 2-methyl-3-bromo-1-propene 

Downstream Products

• 160750-61-8 3-methyl-1-[(4-methylphenyl)-sulfonyl]-2,5-dihydro-1H-pyrrole 
• 663605-00-3 4-methyl-N-(2-oxo-ethyl)-N-(2-oxo-propyl)-benzenesulfonamide 
• 1392282-89-1 1-(3-methylpyrrolidin-1-yl)-2,2-diphenylethanone 
• 1392282-83-5 1-(3-methyl-2,5-dihydro-1H-pyrrol-1-yl)-2,2-diphenylethanone 
• 86553-37-9 3-methyl-1-tosylpyrrolidine 
• 153633-33-1 3-methyl-1-(4-methylbenzenesulphonyl)-1H-pyrrole 
• 1400471-16-0 C₁₂H₁₅NO₂S 
• 156222-29-6 3-methyl-2-pyrrolin-1-yl p-tolyl sulfone 
• 1202400-56-3 4,4-dimethyl-3-hydroxylmethyl-1-tosylpyrrolidine 
• 1202400-50-7 3-chloromethyl-4,4-dimethyl-1-tosylpyrrolidine 
• 1202400-67-6 3-chloromethyl-3,4-dimethyl-1-tosylpyrrolidine 

Relevant academic research and scientific papers

A medium fluorous Grubbs-Hoveyda 2nd generation catalyst for phase transfer catalysis of ring closing metathesis reactions

A fluorous Grubbs-Hoveyda metathesis catalyst supported on Teflon powder, that readily moves between the solid phase (Teflon) and the liquid phase (DMF) was prepared. By modulating the hydrophobicity of the reaction medium at the end of the reaction, the supported catalyst could be recovered by simple filtration even though the catalyst existed in a homogeneous state during the reaction. In RCM reactions, the catalyst could be reused up to three times with only a slight loss in reactivity with each subsequent cycle.

PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Chiral hetero- and carbocyclic compounds from the asymmetric hydrogenation of cyclic alkenes

Several types of chiral hetero- and carbocyclic compounds have been synthesized by using the asymmetric hydrogenation of cyclic alkenes. N,P-Ligated iridium catalysts reduced six-membered cyclic alkenes with various substituents and heterofunctionality in good to excellent enantioselectivity, whereas the reduction of five-membered cyclic alkenes was generally less selective, giving modest enantiomeric excesses. The stereoselectivity of the hydrogenation depended more strongly on the substrate structure for the five- rather than the six-membered cyclic alkenes. The major enantiomer formed in the reduction of six-membered alkenes could be predicted from a selectivity model and isomeric alkenes had complementary enantioselectivity, giving opposite optical isomers upon hydrogenation. The utility of the reaction was demonstrated by using it as a key step in the preparation of chiral 1,3-cis-cyclohexane carboxylates. Copyright

Assisted tandem catalytic RCM-aromatization in the synthesis of pyrroles and furans

An assisted tandem catalytic transformation of diallyl amines and diallyl ethers into N-aryl pyrroles and furans, respectively, is described. The sequence relies on ring closing metathesis followed by dehydrogenation of the initially formed dihydropyrroles and dihydrofurans. Both steps are Ru-catalyzed, but the sequence requires only one precatalyst, because conversion of the metathesis catalyst into the dehydrogenation catalyst is achieved in situ, triggered by the oxidant tert-butyl hydroperoxide.

Ring size-selective ring-closing olefin metathesis: Taking advantage of the deleterious effect of ethylene gas

The deleterious effect of ethylene gas on the ring-closing olefin metathesis (RCM) for the formation of 5- to 8-membered rings was investigated. Significant rate differences caused by ethylene gas were observed among the different ring-size formation reac

Cycloisomerization promoted by the combination of a ruthenium-carbene catalyst and trimethylsilyl vinyl ether, and its application in the synthesis of heterocyclic compounds: 3-Methylene-2,3-dihydroindoles and 3-methylene-2,3- dihydrobenzofurans

Substituted N and O heterocycles have been synthesized by the cycloisomerization of dienes using a ruthenium-carbene catalyst. The products obtained with and without trimethylsilyl vinyl ether differ (see scheme, Cy = cyclohexyl, Mes = 2,4,6-trimethylphenyl, Ts = p-toluenesulfonyl).

Poly(fluoroalkyl acrylate)-Bound Ruthenium Carbene Complex: A Fluorous and Recyclable Catalyst for Ring-Closing Olefin Metathesis

The synthesis of a fluorous olefin metathesis catalyst derived from the Grubbs second-generation ruthenium carbene complex is described. The air stable fluorous polymer-bound ruthenium carbene complex 1 shows high reactivity in effecting the ring-closing

Synthesis of N-heterocyclic diols by diastereoselective pinacol coupling reactions

A series of 5-8 membered N-heterocyclic diols have been prepared from acyclic dicarbonyls via diastereoselective pinacol reactions whereby cis- or trans-diol stereoselectivity is controlled by the choice of low-valent metal reagent used.