(S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

Base Information

Chemical Name:(S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol
CAS No.:913355-72-3
Molecular Formula:C₁₇H₂₄INO₃
Molecular Weight:417.287
Hs Code.:

Synonyms:(S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

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Chemical Property of (S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

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Technology Process of (S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

There total 5 articles about (S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 913355-71-2
(S)-3-[(S)-5-((S)-3-Benzyloxy-1-hydroxy-propyl)-4,5-dihydro-isoxazol-3-yl]-butan-1-ol

: 913355-72-3
(S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1002/anie.200601655

Reference yield:

: (S)-2-Methyl-4-triisopropylsilanyloxy-butyraldehyde oxime

: 913355-72-3
(S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert-BuOCl / CH₂Cl₂ / -78 °C

1.2: EtMgBr / CH₂Cl₂; propan-2-ol

2.1: tetra-n-butylammonium fluoride / tetrahydrofuran

3.1: 83 percent / iodine; imidazole; triphenylphosphine / tetrahydrofuran

With 1H-imidazole; tert-butylhypochlorite; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200601655

Reference yield:

: (S)-3-Benzyloxy-1-[(S)-3-((S)-1-methyl-3-triethylsilanyloxy-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

: 913355-72-3
(S)-3-Benzyloxy-1-[(S)-3-((S)-3-iodo-1-methyl-propyl)-4,5-dihydro-isoxazol-5-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-n-butylammonium fluoride / tetrahydrofuran

2: 83 percent / iodine; imidazole; triphenylphosphine / tetrahydrofuran

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1002/anie.200601655