(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester
CAS No.:872864-33-0
Molecular Formula:C₄₀H₄₈N₈O₆
Molecular Weight:736.871
Hs Code.:

(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

Synonyms:(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

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Chemical Property of (S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

There total 11 articles about (S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 872864-36-3
(S)-2-[4-((S)-1-Azido-2-phenyl-ethyl)-[1,2,3]triazol-1-yl]-3-phenyl-propionic acid methyl ester

: 143327-80-4
((S)-5-tert-Butoxycarbonylamino-hept-6-ynyl)-carbamic acid benzyl ester

: 872864-33-0
(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/ja056406z

Reference yield: 92.0%

: 872864-31-8
(S)-2-[4-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-[1,2,3]triazol-1-yl]-3-phenyl-propionic acid methyl ester

: 143327-80-4
((S)-5-tert-Butoxycarbonylamino-hept-6-ynyl)-carbamic acid benzyl ester

: 872864-33-0
(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

Guidance literature:: (S)-2-[4-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-[1,2,3]triazol-1-yl]-3-phenyl-propionic acid methyl ester; With trifluoroacetic acid; In dichloromethane;

With triflic azide; copper(II) sulfate; triethylamine; In methanol; dichloromethane; water; at 20 ℃; for 18h;

((S)-5-tert-Butoxycarbonylamino-hept-6-ynyl)-carbamic acid benzyl ester; With tert-Butyl 2,2,2-trichloroacetimidate; copper(II) sulfate; sodium L-ascorbate; In methanol; dichloromethane; water; Further stages.; microwave irradiation;
DOI:10.1021/jo701292h

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 872864-33-0
(S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuSO₄*5H₂O; triethylamine; triflic azide / H₂O; CH₂Cl₂; methanol / 18 h / 20 °C

1.2: 96 percent / TBTA; sodium L-ascorbate; CuSO₄*5H₂O / H₂O; CH₂Cl₂; methanol / 0.08 h / 100 °C / microwave irradiation

2.1: TFA / CH₂Cl₂

2.2: CuSO₄*5H₂O; triethylamine; triflic azide / H₂O; CH₂Cl₂; methanol / 18 h / 20 °C

2.3: 92 percent / TBTA; sodium L-ascorbate; CuSO₄*5H₂O / H₂O; CH₂Cl₂; methanol / microwave irradiation

With triflic azide; copper(II) sulfate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; 1.2: Huisgen 1,3-dipolar cycloaddition / 2.3: Huisgen 1,3-dipolar cycloaddition;
DOI:10.1021/jo701292h