143327-80-4

Basic information

• Product Name: Carbamic acid, [(5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-heptynyl]-, phenylmethyl ester
• CAS NO: 143327-80-4
• Molecular Formula: C20H28N2O4
• Molecular Weight: 360.453
• Mol File: 143327-80-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-heptynyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-heptynyl]-, phenylmethyl ester(143327-80-4)
• EPA Substance Registry System: Carbamic acid, [(5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-heptynyl]-, phenylmethyl ester(143327-80-4)

Safety Data

• Hazardous Substances Data: 143327-80-4(Hazardous Substances Data)

Upstream product

• 82689-16-5 benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate 
• 27491-70-9 dimethyl diazomethylphosphonate 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 872864-29-4 (7,7-dibromo-5-tert-butoxycarbonylamino-hept-6-enyl)-carbamic acid benzyl ester 

Downstream Products

• 143327-94-0 [(E)-(S)-5-tert-Butoxycarbonylamino-7-(2-oxo-tetrahydro-pyran-4-yl)-hept-6-enyl]-carbamic acid benzyl ester 
• 872864-33-0 (S)-2-(4-{(S)-1-[4-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester 
• 1240283-68-4 benzyl [(5S)-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hept-6-yn-1-yl]carbamate 
• 872864-38-5 (S)-2-(4-{(S)-1-[4-((S)-1-Azido-5-benzyloxycarbonylamino-pentyl)-[1,2,3]triazol-1-yl]-2-phenyl-ethyl}-[1,2,3]triazol-1-yl)-3-phenyl-propionic acid methyl ester 
• 143327-87-1 ((E)-(S)-5-tert-Butoxycarbonylamino-7-iodo-hept-6-enyl)-carbamic acid benzyl ester 

Relevant articles and documents

Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates

The 1,2,3-triazole moiety can be incorporated as a peptide bond bioisostere to provide protease resistance in peptidomimetics. Herein, we report the synthesis of peptidomimetic building blocks containing backbone-fluorinated 1,4-disubstituted 1,2,3-triazole moieties. Synthetic protocols for the preparation of various Xaa-Gly dipeptide surrogates in the form of Xaa-ψ[triazole]-F2Gly building blocks were established, and selected examples were introduced into the endogenous peptide opioid receptor ligand Leu-enkephalin as a model compound.

Methods for preparing nonpeptidic oligomers from amino acids

The present invention relates to nonpeptidic oligomers. Methods for preparing nonpeptidic oligomers from amino acids by replacing the amide bond with heterocyclic rings are also disclosed.

Preparation and Reactions of Chiral Propargylic Amines

Exposure of chiral amino aldehydes (1) to dimethyl diazophosphonate (4) affords propargylic amines (2) of high optical purity.Chain extension of these intermediates is readily accomplished via hydrozirconation of the acetylene moiety and subsequent Ni(II) catalyzed Michael addition to a variety of Michael acceptors.