TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE
• CAS No.: 182621-53-0
• Molecular Formula: C19H28 N2 O3
• Molecular Weight: 332.44
• Hs Code.: 2933399090
• Mol file: 182621-53-0.mol

Synonyms:TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE

Chemical Property of TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE

Chemical Property:

• Refractive Index: 1.548
• PSA: 49.85000
• LogP: 3.32900

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-[acetyl(methyl)amino]-4-phenylpiperidine-1-carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE

There total 5 articles about TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Acetylamino-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester (182621-52-9) + methyl iodide (74-88-4) → 4-(Acetyl-methyl-amino)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester (182621-53-0)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; at 40 ℃; for 24h;

DOI:10.1016/0960-894X(96)00419-2

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 4-(Acetyl-methyl-amino)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester (182621-53-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / tetrahydrofuran

2: 80 percent / H₂SO₄ / acetonitrile

3: H₂ / Pd/C / ethanol

4: TEA / dimethylformamide

5: 70 percent / KOH, TBAB / tetrahydrofuran / 24 h / 40 °C

With potassium hydroxide; TEA; sulfuric acid; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0960-894X(96)00419-2

Reference yield:

phenyllithium (591-51-5) → 4-(Acetyl-methyl-amino)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester (182621-53-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / tetrahydrofuran

2: 80 percent / H₂SO₄ / acetonitrile

3: H₂ / Pd/C / ethanol

4: TEA / dimethylformamide

5: 70 percent / KOH, TBAB / tetrahydrofuran / 24 h / 40 °C

With potassium hydroxide; TEA; sulfuric acid; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0960-894X(96)00419-2

upstream raw materials:

4-Acetylamino-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester

methyl iodide

1-phenylmethyl-4-piperidone

phenyllithium

Downstream raw materials:

(S)-(N)-(1-(3-(1-benzoyl-3(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide

osanetant

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