ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

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Chemical Name:ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate
CAS No.:1268476-90-9
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

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Chemical Property of ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

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Technology Process of ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

There total 7 articles about ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1268476-79-4
ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-{[(trifluoromethyl) sulfonyl]oxy}-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

: 1268476-90-9
ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: With formic acid; tributylphosphine; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; for 8h; Reflux; Inert atmosphere;

Reference yield:

: 883528-73-2
3-amino-4-methyl crotonic acid methylester

: 1268476-90-9
ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium ethanolate / ethanol / 15 h / 150 °C

2: trichlorophosphate / 0.5 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

4: triethylamine / ethanol / 25 h / 80 - 100 °C

5: pyridine / 3 h / 60 °C / Inert atmosphere

6: triethylamine; formic acid; tributylphosphine / palladium diacetate / N,N-dimethyl-formamide / 8 h / Reflux; Inert atmosphere

With pyridine; formic acid; tributylphosphine; sodium ethanolate; potassium carbonate; triethylamine; trichlorophosphate; palladium diacetate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1186188-51-1
ethyl 4-chloro-6-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1268476-90-9
ethyl 6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

2: triethylamine / ethanol / 25 h / 80 - 100 °C

3: pyridine / 3 h / 60 °C / Inert atmosphere

4: triethylamine; formic acid; tributylphosphine / palladium diacetate / N,N-dimethyl-formamide / 8 h / Reflux; Inert atmosphere

With pyridine; formic acid; tributylphosphine; potassium carbonate; triethylamine; palladium diacetate; In ethanol; N,N-dimethyl-formamide;