(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

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Chemical Name:(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde
CAS No.:150007-95-7
Molecular Formula:C₂₀H₁₇NO₃S
Molecular Weight:351.426
Hs Code.:

Synonyms:(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

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Chemical Property of (+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

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Technology Process of (+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

There total 3 articles about (+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 150007-90-2
(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine

: 150007-95-7
(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

Guidance literature:: With trichlorophosphate; at 50 ℃; for 3.5h;
DOI:10.1021/jm00022a005

Reference yield:

: 132407-65-9
N-(2-fluorophenyl)pyrrole-2-carboxaldehyde

: 150007-95-7
(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / tetrahydrofuran / 4 h / Heating

2: 1.) triphenylphosphine, DiPAD / 1.) THF, 30 min, 0 deg C, 2.) THF, a) 0 deg C, 5 h, b) RT, 3 h

3: 1.) sodium methoxide, 2.) NaH / 1.) MeOH, RT, 1 h, 2.) DMF, 80 deg C, 1 h

4: 91 percent / phosphorus oxychloride / 3.5 h / 50 °C

With sodium methylate; sodium hydride; diisopropyl (E)-azodicarboxylate; triphenylphosphine; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jm00022a005

Reference yield:

: 138109-49-6
2,4-dimethoxyphenylmagnesium bromide

: 150007-95-7
(+/-)-4-(2',4'-dimethoxyphenyl)-4H-pyrrolo<2,1-c><1,4>benzothiazine-1-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / tetrahydrofuran / 4 h / Heating

2: 1.) triphenylphosphine, DiPAD / 1.) THF, 30 min, 0 deg C, 2.) THF, a) 0 deg C, 5 h, b) RT, 3 h

3: 1.) sodium methoxide, 2.) NaH / 1.) MeOH, RT, 1 h, 2.) DMF, 80 deg C, 1 h

4: 91 percent / phosphorus oxychloride / 3.5 h / 50 °C

With sodium methylate; sodium hydride; diisopropyl (E)-azodicarboxylate; triphenylphosphine; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jm00022a005