2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

Base Information

Chemical Name:2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester
CAS No.:182866-63-3
Molecular Formula:C₁₅H₁₈N₂O₆
Molecular Weight:322.318
Hs Code.:

Synonyms:2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

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Chemical Property of 2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

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Technology Process of 2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

There total 4 articles about 2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 41172-77-4
(±)-2-amino-3-oxo-butyric acid methyl ester hydrochloride

: 182866-63-3
2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

Guidance literature:: N-(Benzyloxycarbonyl)glycine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -25 ℃; for 2h; Inert atmosphere;

(±)-2-amino-3-oxo-butyric acid methyl ester hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; at -25 - 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/acs.joc.7b00185

Reference yield: 76.0%

: 24762-04-7
2-Diazo-3-oxo-butyric acid methyl ester

: 949-90-6
N-(carbobenzyloxy)glycinamide

: 182866-63-3
2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

Guidance literature:: dirhodium tetraacetate; In chloroform; Heating;
DOI:10.1039/a805762a

Reference yield:

: 55378-79-5
C₁₃H₁₅NO₆

: 182866-63-3
2-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NH₃ / tetrahydrofuran / 0.75 h / -10 °C

2: 71 percent / Rh₂(OAc)4 / CHCl₃ / 0.5 h / Heating

With ammonium hydroxide; dirhodium tetraacetate; In tetrahydrofuran; chloroform;
DOI:10.1039/a704093h