Tpmpa

Base Information

Chemical Name:Tpmpa
CAS No.:182485-36-5
Molecular Formula:C₆H₁₂NO₂P
Molecular Weight:161.141
Hs Code.:
UNII:TR7I0800L2
DSSTox Substance ID:DTXSID801017153
Nikkaji Number:J786.339J
Wikipedia:(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic_acid
Wikidata:Q4540639
Pharos Ligand ID:ZJU4RDMQBVND
ChEMBL ID:CHEMBL397209
Mol file:182485-36-5.mol

Synonyms:(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid;TPMPA cpd

Suppliers and Price of Tpmpa

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TPMPA
10mg
$ 423.00

TRC
TPMPA
10mg
$ 130.00

Tocris
TPMPA ≥98%(HPLC)
50
$ 718.00

Tocris
TPMPA ≥98%(HPLC)
10
$ 170.00

Sigma-Aldrich
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate ≥97% (NMR), solid
10mg
$ 239.00

Sigma-Aldrich
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate ≥97% (NMR), solid
50mg
$ 837.00

Medical Isotopes, Inc.
TPMPA
10 mg
$ 625.00

Medical Isotopes, Inc.
TPMPA
50 mg
$ 1025.00

DC Chemicals
TPMPA >98%
1 g
$ 1800.00

DC Chemicals
TPMPA >98%
100 mg
$ 450.00

Total 12 raw suppliers

Chemical Property of Tpmpa

Chemical Property:

Melting Point:252-254°
PSA：59.14000
LogP:1.09260
Storage Temp.:Store at RT
Solubility.:H2O: 16 mg/mL
XLogP3:-3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:161.06056562
Heavy Atom Count:10
Complexity:200

Purity/Quality:

97% ^*data from raw suppliers

TPMPA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CP(=O)(C1=CCNCC1)O
General Description (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) is a highly selective competitive antagonist for GABA_C receptors, playing a role in modulating inhibitory neurotransmission in the central nervous system. It can be synthesized via palladium-catalyzed cross-coupling reactions, with optimized conditions involving Pd(OAc)₂/dppp as a catalyst in refluxing benzene or tetrahydrofuran. (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID is structurally related to GABA analogs, and its synthetic intermediate serves as a precursor for other biologically active derivatives. Elevated temperatures during synthesis (>70°C) may lead to undesired pyridine formation.

Technology Process of Tpmpa

There total 10 articles about Tpmpa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 215930-30-6
isopropyl [1-(2,2,2-trichloroethoxycarbonyl)-1,2,5,6-tetrahydropyridin-4-yl]methylphosphinate

: 182485-36-5
(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid

Guidance literature:: With hydrogen bromide; acetic acid; for 30h; Heating;
DOI:10.1039/b105989k

Reference yield: 93.0%

: 190127-12-9
4-(Methoxy-methyl-phosphinoyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

: 182485-36-5
(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid

Guidance literature:: With hydrogen bromide; acetic acid; for 72h; Heating;
DOI:10.1016/0960-894X(96)00364-2

Reference yield: 60.0%

: 464194-36-3
4-hydroxyphosphinoyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 74-88-4
methyl iodide

: 182485-36-5
(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid

: (1,2,3,6-tetrahydropyridin-4-yl)-phosphonic acid

Guidance literature:: 4-hydroxyphosphinoyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; methyl iodide; With chloro-trimethyl-silane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 - 23 ℃;

With Dowex-50W; water;
DOI:10.1016/S0022-328X(02)01271-8