7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one

Base Information

• Chemical Name: 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one
• CAS No.: 1192871-75-2
• Molecular Formula: C₁₄H₉F₃N₂OS
• Molecular Weight: 310.299
• Mol file: 1192871-75-2.mol

Synonyms:7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one

Chemical Property of 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one

There total 3 articles about 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one (700-52-7) → 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one (1192871-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate; iodine / acetonitrile / 2 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene; water / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium cerium (IV) nitrate; iodine; sodium carbonate; In ethanol; water; toluene; acetonitrile; 2: |Suzuki Coupling;

DOI:10.1002/jhet.3198

Reference yield:

6-iodo-7-methylthiazolo[3,2-a]pyrimidin-5-one (1192871-72-9) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one (1192871-75-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; Reflux;

DOI:10.1002/jhet.3198

Reference yield:

→ 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one (1192871-75-2)

Guidance literature:

upstream raw materials:

7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

6-iodo-7-methylthiazolo[3,2-a]pyrimidin-5-one

4-trifluoromethoxyphenylboronic acid

Downstream raw materials:

7-[(E)-2-(2-cyclopropylmethoxyphenyl)vinyl]-6-[4-(trifluoromethyl)phenyl]-5H-[1,3]-thiazolo[3,2-a]pyrimidin-5-one