2-Chloro-6-benzyloxypyridine-4-carboxylic acid

Base Information

• Chemical Name: 2-Chloro-6-benzyloxypyridine-4-carboxylic acid
• CAS No.: 182483-63-2
• Molecular Formula: C13H10 Cl N O3
• Molecular Weight: 263.68
• DSSTox Substance ID: DTXSID80376275
• Wikidata: Q82165172
• Mol file: 182483-63-2.mol

Synonyms:182483-63-2;2-Chloro-6-benzyloxypyridine-4-carboxylic acid;2-chloro-6-phenylmethoxypyridine-4-carboxylic acid;2-benzyloxy-6-chloro-isonicotinic acid;2-(Benzyloxy)-6-chloroisonicotinic acid;SCHEMBL731278;DTXSID80376275;KMMINKCWBOCELM-UHFFFAOYSA-N;2-benzyloxy-6-chloroisonicotinic acid;AKOS009350332;2-BENZYLOXY-6-CHLORO-ISONICOTINICACID;FT-0611842

Chemical Property of 2-Chloro-6-benzyloxypyridine-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.04E-10mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 497.3°C at 760 mmHg
• Flash Point: 254.6°C
• PSA: 59.42000
• Density: 1.374g/cm³
• LogP: 3.01220
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 263.0349209
• Heavy Atom Count: 18
• Complexity: 281

Purity/Quality:

98%Min ^*data from raw suppliers

2-BENZYLOXY-6-CHLORO-ISONICOTINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=NC(=CC(=C2)C(=O)O)Cl

Technology Process of 2-Chloro-6-benzyloxypyridine-4-carboxylic acid

There total 3 articles about 2-Chloro-6-benzyloxypyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) + benzyl alcohol (100-51-6,185532-71-2) → 2-chloro-6-benzyloxypyridine-4-carboxylic acid (182483-63-2)

Guidance literature:

benzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

2,6-dichloropyridine-4-carboxylic acid; In N,N-dimethyl-formamide; at 0 - 90 ℃;

Reference yield:

methyl 2-(benzyloxy)-6-chloroisonicotinate (182483-64-3) → 2-chloro-6-benzyloxypyridine-4-carboxylic acid (182483-63-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

Reference yield:

methyl 2,6-dichloroisonicotinate (42521-09-5) + benzyl alcohol (100-51-6,185532-71-2) → 2-chloro-6-benzyloxypyridine-4-carboxylic acid (182483-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran

With sodium hydride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2,6-dichloropyridine-4-carboxylic acid

benzyl alcohol

methyl 2,6-dichloroisonicotinate

methyl 2-(benzyloxy)-6-chloroisonicotinate

Refernces

• 1、 -. "SPIROCHROMANON DERIVATIVES". Page/Page column 125. . Retrieved 2008/12/07.