182483-64-3

Basic information

• Product Name: methyl 2-(benzyloxy)-6-chloroisonicotinate
• Synonyms: methyl 2-(benzyloxy)-6-chloroisonicotinate
• CAS NO: 182483-64-3
• Molecular Weight: 277.707
• Mol File: 182483-64-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-(benzyloxy)-6-chloroisonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(benzyloxy)-6-chloroisonicotinate(182483-64-3)
• EPA Substance Registry System: methyl 2-(benzyloxy)-6-chloroisonicotinate(182483-64-3)

Safety Data

• Hazardous Substances Data: 182483-64-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1041204-87-8 methyl 2-phenyl-6-benzyloxypyridine-4-carboxylate 
• 182483-63-2 2-chloro-6-benzyloxypyridine-4-carboxylic acid 

Relevant articles and documents

USE OF PYRIDYLOXYPYRIDINES FOR TREATING INFECTIOUS DISEASES

Provided herein are methods of treating a viral infection in a subject in need thereof, comprising administering to the subject a compound of Formula (I), or a pharmaceutical composition comprising Formula (I). Further provided herein are methods for inhibiting the replication of a virus (e.g., a togaviridae family virus (e.g., an alphavirus (e.g., Chikungunya virus, Eastern equine encephalitis, Mayaro virus, Venezuelan equine encephalitis virus, Western equine encephalitis)), a filoviradae family virus (e.g., a Marburg virus (e.g., Marburg virus, Ravn virus)), human respiratory syncytial virus (i.e., human orthopneumo viru s ), a flavivirus (e.g., dengue virus, Usutu virus, Japanese encephalitis virus, Powassan virus, yellow fever), a paramyxoviridae family virus (e.g., an orthoparamyxovirinae virus (e.g., a henipavims (e.g., Nipah virus), a morbillivims (e.g., measles morbillivirus))) in a subject in need thereof. Also provided herein are methods for treating and/or preventing a disorder due to a microbial toxin (e.g., due to P. aeruginosa exotoxin A, Clostridium septicum alpha-toxin, diphtheria toxin(s), shiga toxin(s)) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutical composition comprising a compound of Formula (I) as described herein. Also provided are pharmaceutical compositions and kits including a compound of Formula (I) for use in the treatment and/or prevention of a viral infection in a subject in need thereof.

BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE

Provided herein are novel compounds of Formulae I-III, and methods of using the same to selectively inhibit BACE2.