[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

Base Information

Chemical Name:[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester
CAS No.:905293-38-1
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid <i>tert</i>-butyl ester

Synonyms:[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

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Chemical Property of [4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

Chemical Property:

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Technology Process of [4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

There total 8 articles about [4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 587880-25-9
4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester

: 5292-43-3
bromoacetic acid tert-butyl ester

: 905293-38-1
[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: 4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃;

bromoacetic acid tert-butyl ester; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 - 50 ℃;
DOI:10.1021/jm051134w

Reference yield:

: 583825-27-8
1-(4-azidobutyl)-4-methoxybezene

: 905293-38-1
[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / Ph₃P; H₂O / tetrahydrofuran / 20 °C

2.1: 90 percent / aq. HBr / 3 h / Heating

3.1: 62 percent / sodium bicarbonate / dioxane; H₂O / -2 - 20 °C

4.1: NaH / tetrahydrofuran / 0 °C

4.2: 99 percent / tetrabutylammonium iodide / tetrahydrofuran / 20 - 50 °C

With water; hydrogen bromide; sodium hydride; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm051134w

Reference yield:

: 4-(4-hydroxyphenyl)butylamine hydrobromide

: 905293-38-1
[4-(4-benzyloxycarbonylamino-butyl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 62 percent / sodium bicarbonate / dioxane; H₂O / -2 - 20 °C

2.1: NaH / tetrahydrofuran / 0 °C

2.2: 99 percent / tetrabutylammonium iodide / tetrahydrofuran / 20 - 50 °C

With sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm051134w