4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

Base Information

• Chemical Name: 4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester
• CAS No.: 107813-00-3
• Molecular Formula: C₁₂H₁₀ClNO₅
• Molecular Weight: 283.668

Synonyms:4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

Chemical Property of 4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

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Technology Process of 4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

There total 1 articles about 4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 4-chloroacetoacetate (32807-28-6,935731-94-5) + 3-nitro-benzaldehyde (99-61-6) → 4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester (107813-00-3)

Guidance literature:

With acetic acid; benzylamine; In isopropyl alcohol; for 20h; Ambient temperature;

DOI:10.1021/jm00164a028

Reference yield: 80.0%

4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester (107813-00-3) + 3-(4-dimethylamino-anilino)-crotonic acid ethyl ester (42792-93-8) → 2-Chloromethyl-1-(4-dimethylamino-phenyl)-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Heating;

DOI:10.1007/BF02253029

Reference yield: 60.0%

4-Chloro-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester (107813-00-3) + ethyl β-(p-methoxyphenylamino)crotonate (201990-83-2) → 2-Chloromethyl-1-(4-methoxy-phenyl)-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Heating;

DOI:10.1007/BF02253029

upstream raw materials:

Methyl 4-chloroacetoacetate

3-nitro-benzaldehyde

Downstream raw materials:

2-[1-Chloro-meth-(Z)-ylidene]-1-(4-methoxy-phenyl)-6-methyl-4-(3-nitro-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester

2-[1-Chloro-meth-(Z)-ylidene]-1-(4-ethoxy-phenyl)-6-methyl-4-(3-nitro-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester

2-Chloromethyl-1-(4-ethoxy-phenyl)-2-hydroxy-6-methyl-4-(3-nitro-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester

2-Imidazol-1-ylmethyl-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

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