3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol

Base Information

• Chemical Name: 3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol
• CAS No.: 182250-70-0
• Molecular Formula: C39H44 O3 Si2
• Molecular Weight: 616.948
• DSSTox Substance ID: DTXSID80455630
• Nikkaji Number: J1.074.979D
• Wikidata: Q82277720
• Mol file: 182250-70-0.mol

Synonyms:182250-70-0;3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol;(3,5-Bis((tert-butyldiphenylsilyl)oxy)phenyl)methanol;[3,5-bis[[tert-butyl(diphenyl)silyl]oxy]phenyl]methanol;DTXSID80455630;MFCD02093440;AKOS015837863;B2052;3,5-bis(t-butyldiphenylsilyloxy)benzylal-cohol;3,5-Bis(tert-butyldiphenylsiloxy)benzyl alcohol;T70462;3,5 Bis(tert-butyldiphenylsilyloxy)benzylalcohol;3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol, 95%

Chemical Property of 3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 108 °C
• Refractive Index: 1.603
• Boiling Point: 631.648oC at 760 mmHg
• Flash Point: 335.809oC
• PSA: 38.69000
• Density: 1.116g/cm3
• LogP: 7.05650
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 11
• Exact Mass: 616.28289833
• Heavy Atom Count: 44
• Complexity: 750

Purity/Quality:

98% ^*data from raw suppliers

3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OC3=CC(=CC(=C3)CO)O[Si](C4=CC=CC=C4)(C5=CC=CC=C5)C(C)(C)C

Technology Process of 3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol

There total 3 articles about 3,5-Bis(tert-butyldiphenylsilyloxy)benzyl Alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3,5-bis(tert-butyldiphenylsilyloxy)benzoate (182250-68-6) → 3,5-di-(tert-butyl(diphenyl)silyloxy)benzyl alcohol (182250-70-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Yield given;

DOI:10.1039/CC9960002143

Reference yield:

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → 3,5-di-(tert-butyl(diphenyl)silyloxy)benzyl alcohol (182250-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: LiAlH₄ / tetrahydrofuran / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: silylation / 2: Reduction;

DOI:10.1021/jo005592i

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 3,5-di-(tert-butyl(diphenyl)silyloxy)benzyl alcohol (182250-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: LiAlH₄ / tetrahydrofuran / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: silylation / 2: Reduction;

DOI:10.1021/jo005592i

upstream raw materials:

methyl 3,5-bis(tert-butyldiphenylsilyloxy)benzoate

1-carbomethoxy-3,5-dihydroxybenzene

tert-butylchlorodiphenylsilane

Downstream raw materials:

3,5-dibromo[3',5'-bis(tert-butyldiphenylsiloxy)benzyloxy]benzene

3,5-bis(3,5-bis(4-methoxycarbonylphenyl)benzyloxy)benzyl alcohol