(1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate

Base Information

• Chemical Name: (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate
• CAS No.: 1391026-14-4
• Molecular Formula: C₂₀H₁₉Cl₂N₅O₅
• Molecular Weight: 480.307
• Mol file: 1391026-14-4.mol

Synonyms:(1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate

Chemical Property of (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate

There total 6 articles about (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-azido-1-(morpholin-4-yl)ethan-1-one (864528-04-1) + prop-2-ynyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carboxylate (661452-05-7) → (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate (1391026-14-4)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1002/jhet.837

Reference yield:

2,6-dichlorobenzaldoxime (25185-95-9) → (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate (1391026-14-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: chlorine / methanol / 0 - 5 °C

2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10

2.2: 2 h / 0 - 20 °C / pH 9

3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux

4.1: phosphorus pentachloride / 1 h / 45 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With copper(ll) sulfate pentahydrate; phosphorus pentachloride; water; chlorine; sodium L-ascorbate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; tert-butyl alcohol;

DOI:10.1002/jhet.837

Reference yield:

SPB 06193 (4402-83-9) → (1-(2-morpholino-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-caroboxylate (1391026-14-4)

Guidance literature:

Multi-step reaction with 4 steps

1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux

2: phosphorus pentachloride / 1 h / 45 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With copper(ll) sulfate pentahydrate; phosphorus pentachloride; water; sodium L-ascorbate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; tert-butyl alcohol;

DOI:10.1002/jhet.837

upstream raw materials:

2-azido-1-(morpholin-4-yl)ethan-1-one

prop-2-ynyl 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carboxylate

2,6-dichlorobenzaldoxime

2,6-dichlorobenzaldehyde

Refernces