2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

Base Information

Chemical Name:2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine
CAS No.:1433823-93-8
Molecular Formula:C₂₄H₃₄IN₇O₂Si
Molecular Weight:607.57
Hs Code.:

Synonyms:2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

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Chemical Property of 2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

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Technology Process of 2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

There total 6 articles about 2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1395030-33-7
4-(4-(oxetan-3-yl)piperazin-1-yl)benzenamine

: 552315-16-9
6-chloro-2-iodo-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

: 1433823-93-8
2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

Guidance literature:: With triethylamine; In isopropyl alcohol; at 80 ℃; for 4h;

Reference yield:

: 552315-15-8
6-chloro-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-2-amine

: 1433823-93-8
2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: methyl iodide; copper(l) iodide; isopentyl nitrite / tetrahydrofuran / 1 h / Reflux

2: triethylamine / isopropyl alcohol / 4 h / 80 °C

With copper(l) iodide; triethylamine; methyl iodide; isopentyl nitrite; In tetrahydrofuran; isopropyl alcohol;

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 1433823-93-8
2-iodo-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: methyl iodide; copper(l) iodide; isopentyl nitrite / tetrahydrofuran / 1 h / Reflux

3.1: triethylamine / isopropyl alcohol / 4 h / 80 °C

With copper(l) iodide; sodium hydride; triethylamine; methyl iodide; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;