((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride

Base Information

• Chemical Name: ((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride
• CAS No.: 1105703-27-2
• Molecular Formula: C₂₀H₂₉ClN₂O₂*ClH
• Molecular Weight: 401.376

Synonyms:((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride

Chemical Property of ((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride

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Technology Process of ((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride

There total 1 articles about ((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexylcarbamate (1105702-19-9) → ((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride (1105703-27-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 3h;

Reference yield: 100.0%

((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride (1105703-27-2) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexylcarbamate (1105702-38-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 20h;

Reference yield: 93.0%

((1S,2R)-2-aminocyclohexyl)((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)methanone hydrochloride (1105703-27-2) + phenyl chloroformate (1885-14-9) → phenyl (1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexylcarbamate (1105702-23-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

upstream raw materials:

tert-butyl (1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexylcarbamate

Downstream raw materials:

methyl 3-((1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexylcarbamoyl)benzoate

N-((1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexyl)benzamide

((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)((1S,2R)-2-(m-tolylamino)cyclohexyl)methanone

methyl 5-((1R,2S)-2-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-1-carbonyl)cyclohexyl-carbamoyl)biphenyl-3-carboxylate

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