Technology Process of Benzoic acid, 4-amino-2-ethoxy-3-hydroxy-, methyl ester (9CI)
There total 5 articles about Benzoic acid, 4-amino-2-ethoxy-3-hydroxy-, methyl ester (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; water;
for 1h;
under 3040 Torr;
Ambient temperature;
DOI:10.1248/cpb.44.1484
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH, DMSO / 1.) 110 deg C, 2 h, 2.) RT, 18 h
2: 22 percent / 70percent aq. HNO3, AcOH / toluene / 0.08 h / 5 - 10 °C
3: 77 percent / AgNO3, 1N aq. NaOH / methanol / 6 h / 85 °C
4: 99 percent / SOCl2 / 3 h / Heating
5: 65 percent / H2 / 10percent Pd/C / ethanol; H2O / 1 h / 3040 Torr / Ambient temperature
With
sodium hydroxide; thionyl chloride; hydrogen; nitric acid; sodium hydride; silver nitrate; acetic acid; dimethyl sulfoxide;
palladium on activated charcoal;
In
methanol; ethanol; water; toluene;
DOI:10.1248/cpb.44.1484
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 22 percent / 70percent aq. HNO3, AcOH / toluene / 0.08 h / 5 - 10 °C
2: 77 percent / AgNO3, 1N aq. NaOH / methanol / 6 h / 85 °C
3: 99 percent / SOCl2 / 3 h / Heating
4: 65 percent / H2 / 10percent Pd/C / ethanol; H2O / 1 h / 3040 Torr / Ambient temperature
With
sodium hydroxide; thionyl chloride; hydrogen; nitric acid; silver nitrate; acetic acid;
palladium on activated charcoal;
In
methanol; ethanol; water; toluene;
DOI:10.1248/cpb.44.1484