N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester

Base Information

• Chemical Name: N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester
• CAS No.: 128652-37-9
• Molecular Formula: C₁₉H₂₀ClN₃S
• Molecular Weight: 357.907

Synonyms:N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester

Chemical Property of N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester

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Technology Process of N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester

There total 3 articles about N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-chloro-phenyl)-benzimidoyl isothiocyanate (20800-28-6) → N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester (128652-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone

2: 2) aq. 3 N KOH / 1) acetone, RT, 10 h

With potassium hydroxide; In acetone;

DOI:10.1055/s-1990-26892

Reference yield:

Pyrrolidine-1-carbothioic acid {[(E)-4-chloro-phenylimino]-phenyl-methyl}-amide (128672-83-3) + methyl iodide (74-88-4) → N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester (128652-37-9)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1) acetone, RT, 10 h;

DOI:10.1055/s-1990-26892

Reference yield:

Pyrrolidine-1-carbothioic acid {[(E)-4-chloro-phenylimino]-phenyl-methyl}-amide (128672-83-3) + methyl iodide (74-88-4) → N-{[(E)-4-Chloro-phenylimino]-phenyl-methyl}-pyrrolidine-1-carboximidothioic acid methyl ester (128652-37-9)

Guidance literature:

With potassium hydroxide; Multistep reaction;

DOI:10.1016/S0040-4020(01)86423-1

upstream raw materials:

Pyrrolidine-1-carbothioic acid {[(E)-4-chloro-phenylimino]-phenyl-methyl}-amide

methyl iodide

N-(4-chloro-phenyl)-benzimidoyl isothiocyanate

Pyrrolidine-1-carbothioic acid {[(E)-4-chloro-phenylimino]-phenyl-methyl}-amide

Downstream raw materials:

1-p-chlorophenyl-2,5-diphenyl-4-pyrrolidino-1,6-dihydropyrimdin-6-one

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