(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

Base Information

Chemical Name:(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate
CAS No.:1380805-41-3
Molecular Formula:C₂HF₃O₂*C₃₁H₃₄Cl₂F₂N₂O₂
Molecular Weight:689.55
Hs Code.:

(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

Synonyms:(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

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Chemical Property of (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

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Technology Process of (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

There total 2 articles about (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.8%

: 34756-16-6
3-(5-methylfuran-2-yl)propanal

: 1380805-27-5
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidine-3-carbonitrile

: 76-05-1
trifluoroacetic acid

: 1380805-41-3
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

Guidance literature:: 3-(5-methylfuran-2-yl)propanal; (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidine-3-carbonitrile; With sodium tris(acetoxy)borohydride; acetic acid; at 20 ℃; for 14h;

trifluoroacetic acid;

Reference yield:

: 1354693-60-9
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1380805-41-3
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(5-methyl-furan-2-yl)-propyl]-pyrrolidine-3-carbonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate; lithium chloride / tetrahydrofuran / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 14 h / 20 °C

With methanol; sodium tetrahydroborate; sodium tris(acetoxy)borohydride; acetic acid; lithium chloride; In tetrahydrofuran;