5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

Base Information

Chemical Name:5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide
CAS No.:153198-07-3
Molecular Formula:C₁₉H₂₇BrN₂O₅
Molecular Weight:443.338
Hs Code.:

Synonyms:5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

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Chemical Property of 5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

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Technology Process of 5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

There total 5 articles about 5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 153198-07-3
5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: H₂ / Pearlman's catalyst / methanol / 48 h / 3102.9 Torr

3: 82 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 81 percent / 37percent aq. NH₄OH / methanol / 2 h / Heating

5: 1.) ethyl chloroformate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 2 h

With ammonium hydroxide; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jm00075a028

Reference yield:

: 97181-50-5
N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide

: 153198-07-3
5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pearlman's catalyst / methanol / 48 h / 3102.9 Torr

2: 82 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: 81 percent / 37percent aq. NH₄OH / methanol / 2 h / Heating

4: 1.) ethyl chloroformate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 2 h

With ammonium hydroxide; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jm00075a028

Reference yield:

: 97181-51-6
4-trifluoromethylcarbonylamino piperidine

: 153198-07-3
5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 81 percent / 37percent aq. NH₄OH / methanol / 2 h / Heating

3: 1.) ethyl chloroformate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 2 h

With ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00075a028