N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

Base Information

Chemical Name:N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide
CAS No.:1384878-50-5
Molecular Formula:C₃₂H₃₃F₃N₄O₅
Molecular Weight:610.633
Hs Code.:

N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

Synonyms:N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

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Chemical Property of N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

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Technology Process of N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

There total 7 articles about N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1384878-45-8
C₃₀H₃₁F₃N₄O₄

: 75-36-5
acetyl chloride

: 1384878-50-5
N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 852814-99-4
ethyl 4-[4-(1-methylethyl)phenyl]-2,4-dioxobutanoate

: 1384878-50-5
N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / ethanol / 0.25 h / 20 °C

1.2: Reflux

2.1: triethylamine / dmap / tert-butyl alcohol / 16 h / 60 °C

3.1: trichloroisocyanuric acid / 1,1-dichloroethane / 16 h / Reflux

4.1: sodium azide / N,N-dimethyl-formamide / 5 h / 50 °C

5.1: trimethylphosphane / tetrahydrofuran / 3 h / 20 °C

6.1: triethylamine / dichloromethane / 4 h / 20 °C

With sodium azide; trichloroisocyanuric acid; triethylamine; trimethylphosphane; dmap; acetic acid; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 645-13-6
4-isopropylacetophenone

: 1384878-50-5
N-({6-[3-(tert-butoxy)-2-oxo-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-1-yl]pyridazin-3-yl}methyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol; sodium / 0.5 h / 20 °C

1.2: 16 h / Reflux

2.1: acetic acid / ethanol / 0.25 h / 20 °C

2.2: Reflux

3.1: triethylamine / dmap / tert-butyl alcohol / 16 h / 60 °C

4.1: trichloroisocyanuric acid / 1,1-dichloroethane / 16 h / Reflux

5.1: sodium azide / N,N-dimethyl-formamide / 5 h / 50 °C

6.1: trimethylphosphane / tetrahydrofuran / 3 h / 20 °C

7.1: triethylamine / dichloromethane / 4 h / 20 °C

With sodium azide; ethanol; trichloroisocyanuric acid; sodium; triethylamine; trimethylphosphane; dmap; acetic acid; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;