4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

Base Information

Chemical Name:4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester
CAS No.:1002328-89-3
Molecular Formula:C₂₇H₂₉N₃O₁₃
Molecular Weight:603.54
Hs Code.:

4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1a<i>H</i>-1,8-diaza-benzo[<i>a</i>]cyclopropa[<i>e</i>]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

Synonyms:4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

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Chemical Property of 4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

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Technology Process of 4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

There total 11 articles about 4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125229-14-3
methyl 3-methoxymethyloxy-4-methyl-5-nitrobenzene

: 1002328-89-3
4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / NaOMe

2: imidazole / CH₂Cl₂

3: DDQ / CH₂Cl₂

4: H₂ / Pd/C

5: MgSO₄; 4 Angstroem molecular sieves / CH₂Cl₂

6: NaCNBH₃; AcOH

7: 75 percent / DIPEA

8: TBAF / tetrahydrofuran

With 1H-imidazole; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; sodium cyanoborohydride; magnesium sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; 4: Dess-Martin oxidation / 10: Dess-Martin oxidation;
DOI:10.1021/ol0266774

Reference yield:

: 192061-03-3
(2S-cis)-methyl ester 2-formyl-3-[(4-methoxyphenyl)methoxymethyl]-1-aziridinecarboxylic acid

: 1002328-89-3
4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / NaOMe

2: imidazole / CH₂Cl₂

3: DDQ / CH₂Cl₂

4: H₂ / Pd/C

5: MgSO₄; 4 Angstroem molecular sieves / CH₂Cl₂

6: NaCNBH₃; AcOH

7: 75 percent / DIPEA

8: TBAF / tetrahydrofuran

With 1H-imidazole; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; sodium cyanoborohydride; magnesium sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; 4: Dess-Martin oxidation / 10: Dess-Martin oxidation;
DOI:10.1021/ol0266774

Reference yield:

: 192061-04-4
[2S-(2α,3α)]-methyl ester 2-[1-hydroxy-2-[(4-methoxycarbonyl)-2-(methoxymethoxy)-6-nitrophenyl]ethyl]-3-[[(4-methoxyphenyl)methoxy]methyl]-1-aziridinecarboxylic acid

: 1002328-89-3
4-methoxymethoxy-2-oxo-2,3,9,9a-tetrahydro-1aH-1,8-diaza-benzo[a]cyclopropa[e]cyclooctene-1,6,8-tricarboxylic acid 8-(4,5-dimethoxy-2-nitro-benzyl) ester 1,6-dimethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: imidazole / CH₂Cl₂

2: DDQ / CH₂Cl₂

3: H₂ / Pd/C

4: MgSO₄; 4 Angstroem molecular sieves / CH₂Cl₂

5: NaCNBH₃; AcOH

6: 75 percent / DIPEA

7: TBAF / tetrahydrofuran

With 1H-imidazole; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; magnesium sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; 3: Dess-Martin oxidation / 9: Dess-Martin oxidation;
DOI:10.1021/ol0266774