N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

Base Information

Chemical Name:N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine
CAS No.:1262193-62-3
Molecular Formula:C₂₀H₁₇F₄N₇O
Molecular Weight:447.395
Hs Code.:

Synonyms:N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

Chemical Property:

Purity/Quality:: ≥98% ^*data from raw suppliers

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Technology Process of N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

There total 8 articles about N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1262197-24-9
3-bromo-N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-1H-1,2,4-triazol-5-amine

: 1262197-26-1
C₁₆H₂₂BN₃O₃

: 1262193-62-3
N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 4.5h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: C₁₅H₉F₄N₃O

: 1262193-62-3
N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 2 h / 90 °C

2.1: sodium nitrite; copper(I) bromide; hydrogen bromide / acetonitrile

3.1: caesium carbonate / water; 1,2-dimethoxyethane / 0.08 h / Inert atmosphere

3.2: 80 °C / Inert atmosphere

3.3: 4.5 h / 80 °C / Inert atmosphere

With hydrogen bromide; caesium carbonate; copper(I) bromide; sodium nitrite; In 1,2-dimethoxyethane; water; isopropyl alcohol; acetonitrile; 2.1: |Sandmeyer Reaction / 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.10.024

Reference yield:

: C₁₀H₉F₄N₅

: 1262193-62-3
N-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-1-methyl-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; copper(I) bromide; hydrogen bromide / acetonitrile

2.1: caesium carbonate / water; 1,2-dimethoxyethane / 0.08 h / Inert atmosphere

2.2: 80 °C / Inert atmosphere

2.3: 4.5 h / 80 °C / Inert atmosphere

With hydrogen bromide; caesium carbonate; copper(I) bromide; sodium nitrite; In 1,2-dimethoxyethane; water; acetonitrile; 1.1: |Sandmeyer Reaction / 2.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.10.024