benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

Base Information

Chemical Name:benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate
CAS No.:1309784-03-9
Molecular Formula:C₂₆H₂₈N₄O₂
Molecular Weight:428.534
Hs Code.:

Synonyms:benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

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Chemical Property of benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

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Technology Process of benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

There total 15 articles about benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1309788-63-3
benzyl N-(2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indol-6-yl)-N-methylcarbamate

: 1309784-03-9
benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

Guidance literature:: benzyl N-(2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indol-6-yl)-N-methylcarbamate; With tetrabutyl ammonium fluoride; ethylenediamine; In N,N-dimethyl-formamide; at 90 ℃; for 7h;

With water; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 2979-19-3
3,3-dimethylcyclohexanone

: 1309784-03-9
benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / Inert atmosphere; Cooling with ice

1.2: 20 °C / Cooling with ice

2.1: hydrazine hydrate / methanol / 1 h / Reflux

3.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: triethylamine / dmap / tetrahydrofuran / 1.17 h / 20 °C

5.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.25 h / 110 °C / Inert atmosphere

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Cooling with ice

6.2: pH 5

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere

7.2: 2 h

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

8.2: pH 5

9.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 115 °C / Inert atmosphere

10.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere; Cooling with ice

10.2: 3 h

11.1: ethylenediamine; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 7 h / 90 °C

With potassium phosphate; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; iodine; sodium hydride; hydrazine hydrate; ethylenediamine; triethylamine; potassium hydroxide; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 1309784-03-9
benzyl N-{2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl}-N-methylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 2 h / 20 °C

2.1: dmap / tetrahydrofuran / 2 h / 20 °C

3.1: lithium diisopropyl amide; Triisopropyl borate / hexane; tetrahydrofuran / 2.5 h / -5 °C

3.2: Cooling with ice

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.25 h / 110 °C / Inert atmosphere

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Cooling with ice

5.2: pH 5

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere

6.2: 2 h

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

7.2: pH 5

8.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 115 °C / Inert atmosphere

9.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere; Cooling with ice

9.2: 3 h

10.1: ethylenediamine; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 7 h / 90 °C

With potassium phosphate; Triisopropyl borate; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; ethylenediamine; triethylamine; sodium hydroxide; lithium diisopropyl amide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; toluene;