(4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

Base Information

Chemical Name:(4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone
CAS No.:1274933-22-0
Molecular Formula:C₁₉H₁₉N₃O₂S
Molecular Weight:353.445
Hs Code.:

Synonyms:(4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

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Chemical Property of (4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

Chemical Property:

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Technology Process of (4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

There total 5 articles about (4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100523-84-0
2-bromothiophene-4-carboxylic acid

: 1274933-22-0
(4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 14 h / Reflux

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water; industrial methylated spirit / 6 h / 110 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 1.5 h / 50 °C

4: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h

With sulfuric acid; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; industrial methylated spirit; water; acetonitrile;

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 1187468-02-5
5-(1H-pyrazol-4-yl)-thiophene-3-carboxylic acid

: 1274933-22-0
(4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; for 1h;

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 1274933-22-0
(4-hydroxy-4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 1 h

2: sulfuric acid / 14 h / Reflux

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water; industrial methylated spirit / 6 h / 110 °C / Inert atmosphere

4: sodium hydroxide; water / methanol / 1.5 h / 50 °C

5: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h

With sulfuric acid; water; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; industrial methylated spirit; water; acetonitrile;