N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

Base Information

Chemical Name:N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide
CAS No.:1056635-99-4
Molecular Formula:C₂₄H₂₄N₆O₃S
Molecular Weight:476.559
Hs Code.:

Synonyms:N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

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Chemical Property of N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

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Technology Process of N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

There total 3 articles about N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 263339-24-8
4-(1,1-dioxo-1lambda* 6 *-thiomorpholin-4-ylmethyl)-phenylamine

: 1056636-12-4
4-(2-chloropyrimidin-4-yl)-N-(cyanomethyl)benzamide

: 1056635-99-4
N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; In 1,2-dimeythoxyethane; at 100 ℃; Heating / reflux;

Reference yield:

: 1056636-11-3
{4-[(cyanomethyl)carbamoyl]phenyl}boronic acid

: 1056635-99-4
N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 24 h / 90 °C

2: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos / 1,2-dimeythoxyethane / 100 °C / Heating / reflux

With potassium phosphate; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; johnphos; In 1,2-dimeythoxyethane; toluene; 1: Suzuki Coupling;

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 1056635-99-4
N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C

1.2: 16 h / 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 24 h / 90 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos / 1,2-dimeythoxyethane / 100 °C / Heating / reflux

With potassium phosphate; oxalyl dichloride; sodium hydrogencarbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; johnphos; In dichloromethane; 1,2-dimeythoxyethane; N,N-dimethyl-formamide; toluene; 2.1: Suzuki Coupling;