Technology Process of 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide
There total 10 articles about 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium cyanide; hydroxylamine;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 5 h / Dean-Stark; Reflux
2.1: N,N-dimethyl-formamide / 18 h / Reflux
3.1: sodium hydroxide / methanol / 16 h / 90 °C
3.2: pH Ca.3
4.1: sulfuric acid / 18 h / Dean-Stark; Reflux
5.1: potassium carbonate / water; methanol / 12 h / 20 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C
7.1: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere
With
potassium cyanide; sulfuric acid; hydroxylamine; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 18 h / Reflux
2.1: sodium hydroxide / methanol / 16 h / 90 °C
2.2: pH Ca.3
3.1: sulfuric acid / 18 h / Dean-Stark; Reflux
4.1: potassium carbonate / water; methanol / 12 h / 20 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C
6.1: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere
With
potassium cyanide; sulfuric acid; hydroxylamine; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
