3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

Base Information

Chemical Name:3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide
CAS No.:1446499-66-6
Molecular Formula:C₂₃H₃₂N₂O₄Si
Molecular Weight:428.604
Hs Code.:

Synonyms:3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

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Chemical Property of 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

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Technology Process of 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

There total 10 articles about 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1429653-88-2
methyl 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate

: 1446499-66-6
3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

Guidance literature:: With potassium cyanide; hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1446499-66-6
3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 5 h / Dean-Stark; Reflux

2.1: N,N-dimethyl-formamide / 18 h / Reflux

3.1: sodium hydroxide / methanol / 16 h / 90 °C

3.2: pH Ca_.3

4.1: sulfuric acid / 18 h / Dean-Stark; Reflux

5.1: potassium carbonate / water; methanol / 12 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

7.1: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

With potassium cyanide; sulfuric acid; hydroxylamine; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 150529-73-0
methyl 2-(3-bromophenyl)acetatee

: 1446499-66-6
3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 18 h / Reflux

2.1: sodium hydroxide / methanol / 16 h / 90 °C

2.2: pH Ca_.3

3.1: sulfuric acid / 18 h / Dean-Stark; Reflux

4.1: potassium carbonate / water; methanol / 12 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6.1: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

With potassium cyanide; sulfuric acid; hydroxylamine; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;