2-phenyl-malonamic acid menthyl ester

Base Information

• Chemical Name: 2-phenyl-malonamic acid menthyl ester
• CAS No.: 874016-48-5
• Molecular Formula: C₁₉H₂₇NO₃
• Molecular Weight: 317.428
• Mol file: 874016-48-5.mol

Synonyms:2-phenyl-malonamic acid menthyl ester

Chemical Property of 2-phenyl-malonamic acid menthyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-phenyl-malonamic acid menthyl ester

There total 2 articles about 2-phenyl-malonamic acid menthyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(-)-menthol (2216-51-5) + ethyl 3-amino-3-oxo-2-phenylpropanoate (42798-15-2) → 2-phenyl-malonamic acid menthyl ester (874016-48-5)

Guidance literature:

With dmap; 4 A molecular sieve; In toluene; Heating;

DOI:10.1016/j.tetasy.2005.10.008

Reference yield:

ethyl phenylcyanoacetate (4553-07-5) → 2-phenyl-malonamic acid menthyl ester (874016-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / aq. H₂SO₄ / 3 h

2: 43 percent / DMAP; molecular sieves 4 Angstroem / toluene / Heating

With dmap; 4 A molecular sieve; sulfuric acid; In toluene;

DOI:10.1016/j.tetasy.2005.10.008

Reference yield: 90.0%

2-phenyl-malonamic acid menthyl ester (874016-48-5) → 2-nitrooxy-2-phenyl-malonamic acid menthyl ester

Guidance literature:

With ammonium cerium(IV) nitrate; magnesium sulfate; In acetonitrile; at 20 ℃; for 6h;

DOI:10.1016/j.tetasy.2005.10.008

upstream raw materials:

(-)-menthol

ethyl 3-amino-3-oxo-2-phenylpropanoate

ethyl phenylcyanoacetate

Downstream raw materials:

(-)-2-hydroxy-2-phenyl-malonamic acid menthyl ester

2,2-dimethyl-4-oxo-5-phenyl-oxazolidine-5-carboxylic acid menthyl ester