2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate

Base Information

• Chemical Name: 2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate
• CAS No.: 503441-14-3
• Molecular Formula: C₁₃H₁₂F₆O₅
• Molecular Weight: 362.226
• Mol file: 503441-14-3.mol

Synonyms:2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate

Chemical Property of 2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate

There total 2 articles about 2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

benzaldehyde (100-52-7) + 2-trifluoromethoxyethyl trifluoromethoxyacetate (503441-11-0) → 2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate (503441-14-3)

Guidance literature:

2-trifluoromethoxyethyl trifluoromethoxyacetate; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -85 ℃; for 0.0833333h;

benzaldehyde; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.5h;

DOI:10.1016/S0022-1139(02)00152-5

Reference yield:

1-(trifluoromethoxy)-2-[2-trifluoromethoxyethoxyethane] (329710-73-8) → 2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate (503441-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 47 percent / Mn₂O₇ / CCl₄ / 20 °C

2.1: LiHMDS; HMPA / tetrahydrofuran; diethyl ether / 0.08 h / -85 °C

2.2: 36 percent / tetrahydrofuran; diethyl ether / 0.5 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; manganese (VII)-oxide; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; diethyl ether;

DOI:10.1016/S0022-1139(02)00152-5

Reference yield: 74.0%

2-trifluoromethoxyethyl 3-hydroxy-3-phenyl-2-trifluoromethoxypropionate (503441-14-3) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenyl-2-trifluoromethoxy-propionic acid 2-trifluoromethoxy-ethyl ester

Guidance literature:

With toluene-4-sulfonic acid; for 24h; Heating;

DOI:10.1016/S0022-1139(02)00152-5

upstream raw materials:

benzaldehyde

2-trifluoromethoxyethyl trifluoromethoxyacetate

1-(trifluoromethoxy)-2-[2-trifluoromethoxyethoxyethane]