benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate

Base Information

• Chemical Name: benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate
• CAS No.: 1255041-85-0
• Molecular Formula: C₂₀H₂₁FO₄
• Molecular Weight: 344.383
• Mol file: 1255041-85-0.mol

Synonyms:benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate

Chemical Property of benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate

There total 2 articles about benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1255041-84-9) + 2-bromoprop-2-enoic acid benzyl ester (64473-02-5) → benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate (1255041-85-0)

Guidance literature:

With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere;

Reference yield: 25.0%

→ benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate (1255041-85-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 1h; Inert atmosphere;

Reference yield: 58.0%

benzyl 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)acrylate (1255041-85-0) → 2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)propanoic acid (1255041-86-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 23 ℃; for 1h;

upstream raw materials:

2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-bromoprop-2-enoic acid benzyl ester

Downstream raw materials:

2-(3-fluoro-4-((2-methoxyethoxy)methyl)phenyl)propanoic acid

N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(2-methoxyethoxymethyl)phenyl]propionamide