trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

Base Information

Chemical Name:trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid
CAS No.:1239310-97-4
Molecular Formula:C₂₄H₂₅N₃O₄S
Molecular Weight:451.546
Hs Code.:

Synonyms:trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

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Chemical Property of trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

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Technology Process of trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

There total 7 articles about trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239311-02-4
tert-butyl trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]-cyclohexyloxy}acetate

: 1239310-97-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 65132-43-6
trans-4,4'-dihydroxy-cyclohexylbenzene

: 1239310-97-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide; acetone / 72 h

2: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 18 h

3: BARBITURIC ACID; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 3 h / Reflux

4: triethylamine / dichloromethane / Cooling with ice

5: N-ethyl-N,N-diisopropylamine; palladium diacetate; dmap; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 34.16 h

7: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; BARBITURIC ACID; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1239310-98-5
tert-butyl [trans-4-(4-allyloxyphenyl)cyclohexyloxy]acetate

: 1239310-97-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyloxy}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: BARBITURIC ACID; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 3 h / Reflux

2: triethylamine / dichloromethane / Cooling with ice

3: N-ethyl-N,N-diisopropylamine; palladium diacetate; dmap; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 34.16 h

5: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; BARBITURIC ACID; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;