1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

Base Information

Chemical Name:1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea
CAS No.:56443-40-4
Molecular Formula:C₁₈H₂₃N₃O₄
Molecular Weight:345.398
Hs Code.:

Synonyms:1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

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Chemical Property of 1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

Chemical Property:

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Technology Process of 1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

There total 5 articles about 1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56443-68-6
1-<2-(benzylamino)ethyl>-3-phenylurea

: 56443-40-4
1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane / 16 h / Ambient temperature

2: NaBH₄, MeOH / tetrahydrofuran / 360 h

3: H₂, AcOH / 30percent Pd/C / 1.5 h

With methanol; sodium tetrahydroborate; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00135a015

Reference yield:

: 56443-71-1
ethyl 2-(bezyloxy)-5-(2-bromoacetyl)benzoate

: 56443-40-4
1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane / 16 h / Ambient temperature

2: NaBH₄, MeOH / tetrahydrofuran / 360 h

3: H₂, AcOH / 30percent Pd/C / 1.5 h

With methanol; sodium tetrahydroborate; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00135a015

Reference yield:

: 2-Benzyloxy-5-(2-{benzyl-[2-(3-phenyl-ureido)-ethyl]-amino}-acetyl)-benzoic acid ethyl ester

: 56443-40-4
1-{2-[2-Hydroxy-2-(4-hydroxy-3-hydroxymethyl-phenyl)-ethylamino]-ethyl}-3-phenyl-urea

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄, MeOH / tetrahydrofuran / 360 h

2: H₂, AcOH / 30percent Pd/C / 1.5 h

With methanol; sodium tetrahydroborate; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00135a015