C₁₆H₁₂BrN₅O₂

Base Information

• Chemical Name: C₁₆H₁₂BrN₅O₂
• CAS No.: 1620955-67-0
• Molecular Formula: C₁₆H₁₂BrN₅O₂
• Molecular Weight: 386.208
• Mol file: 1620955-67-0.mol

Synonyms:C₁₆H₁₂BrN₅O₂

Chemical Property of C₁₆H₁₂BrN₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₂BrN₅O₂

There total 4 articles about C₁₆H₁₂BrN₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-(4-bromophenyl)-1,6-naphthyridine-4-carboxylic acid (1054478-77-1) + semicarbazide hydrochloride (563-41-7) → C16H12BrN5O2 (1620955-67-0)

Guidance literature:

2-(4-bromophenyl)-1,6-naphthyridine-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

semicarbazide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate (191338-94-0) → C16H12BrN5O2 (1620955-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

4-aminopyridine (504-24-5) → C16H12BrN5O2 (1620955-67-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / chloroform / 1.17 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: potassium hydroxide; water / ethanol / 2 h / Reflux

3.2: 16 h

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 24 h / 20 °C

With n-butyllithium; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; ethanol; hexane; chloroform; N,N-dimethyl-formamide;

upstream raw materials:

ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

2-(4-bromophenyl)-1,6-naphthyridine-4-carboxylic acid

semicarbazide hydrochloride

4-aminopyridine

Downstream raw materials:

C₁₆H₁₀BrN₅O

5-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-1,3,4-oxadiazol-2-amine