1-{2-[4-(6-Methoxy-3,4-dihydronaphthalen-1-YL)phenoxy]ethyl}pyrrolidine

Base Information

• Chemical Name: 1-{2-[4-(6-Methoxy-3,4-dihydronaphthalen-1-YL)phenoxy]ethyl}pyrrolidine
• CAS No.: 180915-94-0
• Molecular Formula: C23H27 N O2
• Molecular Weight: 349.473
• European Community (EC) Number: 605-911-2
• DSSTox Substance ID: DTXSID20572274
• Nikkaji Number: J3.450.140H
• Wikidata: Q82460568
• Mol file: 180915-94-0.mol

Synonyms:180915-94-0;1-{2-[4-(6-METHOXY-3,4-DIHYDRONAPHTHALEN-1-YL)PHENOXY]ETHYL}PYRROLIDINE;1-[2-[4-(6-methoxy-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;SCHEMBL114809;DTXSID20572274;LNXCMAIFYNBIAO-UHFFFAOYSA-N;1-{2-[4(6-methoxy-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine

Chemical Property of 1-{2-[4-(6-Methoxy-3,4-dihydronaphthalen-1-YL)phenoxy]ethyl}pyrrolidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 503.069°C at 760 mmHg
• Flash Point: 166.353°C
• PSA: 21.70000
• Density: 1.12g/cm³
• LogP: 4.48560
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 349.204179104
• Heavy Atom Count: 26
• Complexity: 463

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(=CCC2)C3=CC=C(C=C3)OCCN4CCCC4

Technology Process of 1-{2-[4-(6-Methoxy-3,4-dihydronaphthalen-1-YL)phenoxy]ethyl}pyrrolidine

There total 6 articles about 1-{2-[4-(6-Methoxy-3,4-dihydronaphthalen-1-YL)phenoxy]ethyl}pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) + 6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 6-methoxy-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydronaphthalene (180915-94-0)

Guidance literature:

With n-butyllithium; CeCl₃; In tetrahydrofuran; diethyl ether;

Reference yield: 57.0%

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) + diethyl ether (60-29-7,927820-24-4) + 6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 6-methoxy-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydronaphthalene (180915-94-0)

Guidance literature:

With n-butyllithium; CeCl₃; In tetrahydrofuran; hydrogenchloride;

Reference yield: 57.0%

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) + n-BuU + diethyl ether (60-29-7,927820-24-4) + 6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 6-methoxy-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydronaphthalene (180915-94-0)

Guidance literature:

CeCl₃; In tetrahydrofuran; hydrogenchloride;

upstream raw materials:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

1-[2-(4-bromophenoxy)ethyl]pyrrolidine

diethyl ether

Downstream raw materials:

1-{2-[4-(2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine

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