5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester
CAS No.:851225-36-0
Molecular Formula:C₁₂H₉F₃N₂O₂S
Molecular Weight:302.277
Hs Code.:

Synonyms:5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

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Chemical Property of 5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

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Technology Process of 5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

There total 1 articles about 5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.9%

: 61689-40-5
2-oxo[1,3,4]oxathiazole-5-carboxylic acid ethyl ester

: 455-18-5
4-CF₃C₆H₄CN

: 851225-36-0
5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

Guidance literature:: In 1,2-dichloro-benzene; at 160 ℃; for 96h;
DOI:10.1021/jm070511x

Reference yield: 93.0%

: 851225-36-0
5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

: 851225-37-1
[5-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-3-yl]methanol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm070511x

Reference yield:

: 851225-36-0
5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-3-carboxylic acid ethyl ester

: 851225-38-2
3-bromomethyl-5-(4-trifluoromethylphenyl)[1,2,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaBH₄ / ethanol / 2 h / 20 °C

2: 72 percent / CBr₄; PPh₃ / CH₂Cl₂ / 2 h / 0 - 20 °C

With sodium tetrahydroborate; carbon tetrabromide; triphenylphosphine; In ethanol; dichloromethane;
DOI:10.1021/jm070511x