trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester
CAS No.:925463-58-7
Molecular Formula:C₃₈H₄₁F₃N₂O₁₀S₂
Molecular Weight:806.878
Hs Code.:

trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1<i>H</i>-indol-5-yl ester

Synonyms:trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

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Chemical Property of trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

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Technology Process of trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

There total 15 articles about trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 925463-53-2
trifluoro-methanesulfonic acid 7-benzyloxy-4-(1-formyl-2-methoxymethoxy-ethyl)-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

: 3287-99-8,39110-74-2,108321-65-9
benzylamine hydrochloride

: 925463-58-7
trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 3h;
DOI:10.1021/jo062064j

Reference yield:

: (2E,4E)-1,6-Bis-methoxymethoxy-hexa-2,4-diene

: 925463-58-7
trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂ / 24 h / 9308660 Torr

2: 0.860 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.5 h

3: 98 percent / sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C

4: osmium tetroxide; 2,6-lutidine; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

5: sodium periodate on silica gel / CH₂Cl₂ / 2.5 h

6: 0.790 g / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.33 h

7: 70 percent / sodium cyanoborohydride / methanol / 3 h / 20 °C

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; sodium hydride; sodium cyanoborohydride; methanesulfonyl chloride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 1: Diels-Alder reaction;
DOI:10.1021/jo062064j

Reference yield:

: 925463-43-0
4-amino-3-benzyloxy-phenol

: 925463-58-7
trifluoro-methanesulfonic acid 4-(2-benzylamino-1-methoxymethoxymethyl-ethyl)-7-benzyloxy-3-methoxymethoxymethyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 84 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

2: 96 percent / sodium periodate on silica gel / CH₂Cl₂ / 4 h

3: CH₂Cl₂ / 24 h / 9308660 Torr

4: 0.860 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.5 h

5: 98 percent / sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C

6: osmium tetroxide; 2,6-lutidine; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

7: sodium periodate on silica gel / CH₂Cl₂ / 2.5 h

8: 0.790 g / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.33 h

9: 70 percent / sodium cyanoborohydride / methanol / 3 h / 20 °C

With pyridine; 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; sodium hydride; sodium cyanoborohydride; methanesulfonyl chloride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 3: Diels-Alder reaction;
DOI:10.1021/jo062064j