Technology Process of 4-hydroxymethylphenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone
There total 10 articles about 4-hydroxymethylphenyl(1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrol-3-yl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C21H18BNO5;
With
sodium hydroxide;
In
water;
at 20 ℃;
for 3h;
With
hydrogenchloride;
In
water;
DOI:10.1016/j.ejmech.2014.04.079
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / 1 h / 0 - 20 °C
2.1: tin(II) chloride dihdyrate / ethyl acetate / 4 h / Reflux
3.1: ethyl acetate / 4 h / Reflux
4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: hydrogenchloride / water; tetrahydrofuran / Inert atmosphere
7.1: tin(IV) chloride / dichloromethane / 0.25 h / 20 °C
7.2: 24 h
8.1: sodium hydroxide / water / 3 h / 20 °C
With
hydrogenchloride; lithium borohydride; n-butyllithium; tin(II) chloride dihdyrate; tin(IV) chloride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate;
7.1: |Friedel-Crafts Acylation / 7.2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.04.079
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water; tetrahydrofuran / Inert atmosphere
2.1: tin(IV) chloride / dichloromethane / 0.25 h / 20 °C
2.2: 24 h
3.1: sodium hydroxide / water / 3 h / 20 °C
With
hydrogenchloride; tin(IV) chloride; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.04.079
