2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol

Base Information

• Chemical Name: 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol
• CAS No.: 169032-13-7
• Molecular Formula: C₁₆H₂₃ClO₃
• Molecular Weight: 298.81
• Mol file: 169032-13-7.mol

Synonyms:2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol

Chemical Property of 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol

There total 6 articles about 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate (169032-12-6) → 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol (169032-13-7)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

2-methyl-2-phenylpropionic acid (826-55-1) → 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol (169032-13-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / LiAlH₄ / diethyl ether

2: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

3: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

4: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

5: 99 percent / NaOH; MeOH / 0.5 h / 20 °C

With methanol; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In carbon disulfide; diethyl ether; benzene; 1: Reduction / 2: Acetylation / 3: Acylation / 4: acetalisation / 5: deacetylation;

DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

2-methyl-2-phenyl-propan-1-ol (2173-69-5) → 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol (169032-13-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

2: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

3: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

4: 99 percent / NaOH; MeOH / 0.5 h / 20 °C

With methanol; sodium hydroxide; aluminium trichloride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In carbon disulfide; benzene; 1: Acetylation / 2: Acylation / 3: acetalisation / 4: deacetylation;

DOI:10.1016/S0014-827X(99)00070-1

upstream raw materials:

2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate

2-methyl-2-phenylpropionic acid

2-methyl-2-phenyl-propan-1-ol

(2-acetoxy-1,1-dimethylethyl)benzene

Downstream raw materials:

(R)-(+)-2-[4-(1-Hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidyl)butyl)phenyl]isobutyronitrile

(S)-(-)-2-[4-(1-Hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidyl)butyl)phenyl]isobutyronitrile

Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate

2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide