2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate

Base Information

• Chemical Name: 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate
• CAS No.: 169032-12-6
• Molecular Formula: C₁₈H₂₅ClO₄
• Molecular Weight: 340.847
• Mol file: 169032-12-6.mol

Synonyms:2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate

Chemical Property of 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate

There total 5 articles about 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethylene glycol (107-21-1) + 2-(4-(4-Chloro-1-oxo-butyl))-phenyl-2-methyl propanyl acetate (169032-11-5) → 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate (169032-12-6)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 24h; Heating;

DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

2-methyl-2-phenylpropionic acid (826-55-1) → 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate (169032-12-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / LiAlH₄ / diethyl ether

2: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

3: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

4: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

With lithium aluminium tetrahydride; aluminium trichloride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In carbon disulfide; diethyl ether; benzene; 1: Reduction / 2: Acetylation / 3: Acylation / 4: acetalisation;

DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

2-methyl-2-phenyl-propan-1-ol (2173-69-5) → 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate (169032-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

2: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

3: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

With aluminium trichloride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In carbon disulfide; benzene; 1: Acetylation / 2: Acylation / 3: acetalisation;

DOI:10.1016/S0014-827X(99)00070-1

upstream raw materials:

ethylene glycol

2-(4-(4-Chloro-1-oxo-butyl))-phenyl-2-methyl propanyl acetate

2-methyl-2-phenylpropionic acid

2-methyl-2-phenyl-propan-1-ol

Downstream raw materials:

(R)-(+)-2-[4-(1-Hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidyl)butyl)phenyl]isobutyronitrile

(S)-(-)-2-[4-(1-Hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidyl)butyl)phenyl]isobutyronitrile

Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate

2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

Refernces