2-(4-fluorobenzyl)benzo[d]thiazole

Base Information

• Chemical Name: 2-(4-fluorobenzyl)benzo[d]thiazole
• CAS No.: 37859-33-9
• Molecular Formula: C₁₄H₁₀FNS
• Molecular Weight: 243.305
• Mol file: 37859-33-9.mol

Synonyms:2-(4-fluorobenzyl)benzo[d]thiazole

Chemical Property of 2-(4-fluorobenzyl)benzo[d]thiazole

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-fluorobenzyl)benzo[d]thiazole

There total 16 articles about 2-(4-fluorobenzyl)benzo[d]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 2-iodophenylamine (615-43-0) → 2-(4-fluorobenzyl)benzo[d]thiazole (37859-33-9)

Guidance literature:

With sulfur; copper(I) thiophene-2-carboxylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; acetonitrile; at 130 ℃; for 10h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7cc09855c

Reference yield: 82.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 2-amino-benzenethiol (137-07-5) → 2-(4-fluorobenzyl)benzo[d]thiazole (37859-33-9)

Guidance literature:

With sulfur; In N,N-dimethyl-formamide; at 110 ℃; for 15h; Sealed tube;

DOI:10.1039/c7ob02430d

Reference yield: 80.0%

1,3-Benzothiazole (95-16-9) + p-fluorotoluene (352-32-9) → 2-(4-fluorobenzyl)benzo[d]thiazole (37859-33-9)

Guidance literature:

With N,N'-difluoro-1,4-diazoniabicyclo<2.2.2>octane bis(tetrafluoroborate); trifluoroacetic acid; In acetonitrile; at 20 ℃; for 24h; Irradiation;

upstream raw materials:

2-amino-benzenethiol

4-Fluorophenylacetyl chloride

2-methylmercaptobenzothiazole

1-chloromethyl-4-fluorobenzene

Downstream raw materials:

3-amino-2-(4-fluorobenzyl)-1,3-benzothiazol-3-ium 4-methylbenzenesulfonate

benzo[d]thiazol-2-yl(4-(dimethylamino)phenyl)methanone