methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1412977-73-1
Molecular Formula:C₂₇H₃₂FN₃O₆S
Molecular Weight:545.632
Hs Code.:

methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Synonyms:methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 20 articles about methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-((S)-1-ethylpyrrolidin-3-yl)-N-methylamine dihydrochloride

: methyl (1aRS,7bSR)-5-(2-carboxymethyl-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412977-73-1
methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: methyl (1aRS,7bSR)-5-(2-carboxymethyl-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;

N-((S)-1-ethylpyrrolidin-3-yl)-N-methylamine dihydrochloride; With triethylamine; In dichloromethane; for 17h;

Reference yield:

: 64241-01-6
methyl 2-amino-6-hydroxybenzoate

: 1412977-73-1
methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water / 2.5 h / 20 °C

2.1: potassium carbonate / toluene; acetone / 8 h / Reflux

3.1: toluene / 3 h / 85 °C / Inert atmosphere

4.1: sodium hydroxide; water; N-benzyl-N,N,N-triethylammonium chloride; Bromoform / 2 h / 60 °C

5.1: zinc; ammonium chloride / ethanol / 6 h / Reflux; Inert atmosphere

6.1: sulfuric acid / methanol / 60 h / Reflux; Inert atmosphere

7.1: dichloromethane; pyridine / 96 h / 20 °C

8.1: sodium hydroxide; methanol / 2 h / 50 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C

9.2: 17 h

With methanol; Bromoform; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In pyridine; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; toluene;

Reference yield:

: 64123-77-9
methyl (3-fluorophenyl)acetate

: 1412977-73-1
methyl (1aRS,7bSR)-5-(2-{[N-((S)-1-ethylpyrrolidin-3-yl)-N-methyl-carbamoyl]-methyl}-4-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 16 h / 20 °C / Cooling with ice

2.1: dichloromethane; pyridine / 96 h / 20 °C

3.1: sodium hydroxide; methanol / 2 h / 50 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C

4.2: 17 h

With methanol; chlorosulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In pyridine; dichloromethane;