tert-butyl N-(3-methylpyridin-4-yl)carbamate

Base Information

• Chemical Name: tert-butyl N-(3-methylpyridin-4-yl)carbamate
• CAS No.: 180253-65-0
• Molecular Formula: C11H16 N2 O2
• Molecular Weight: 208.26
• European Community (EC) Number: 899-012-4
• Mol file: 180253-65-0.mol

Synonyms:180253-65-0;tert-butyl N-(3-methylpyridin-4-yl)carbamate;tert-butyl (3-methylpyridin-4-yl)carbamate;Carbamic acid, (3-methyl-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI);MFCD11976851;SCHEMBL2107971;N-Boc-3-methylpyridin-4-amine;4-(N-Bocamino)-3-methylpyridine;RZPXITSRAQPKRU-UHFFFAOYSA-N;AKOS013325206;SB78090;SY192295;tert-butyl(3-methylpyridin-4-yl)carbamate;4-tert-Butoxycarbonylamino-3-methylpyridine;CS-0195680;EN300-75801;E90660;(3-methylpyridin-4-yl)carbamic acid tert-butyl ester;(3-methyl-pyridin-4-yl)-carbamic acid tert-butyl ester;Z1184857738

Chemical Property of tert-butyl N-(3-methylpyridin-4-yl)carbamate

Chemical Property:

• PSA: 54.45000
• LogP: 2.15890
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 208.121177757
• Heavy Atom Count: 15
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

tert-butylN-(3-methylpyridin-4-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1)NC(=O)OC(C)(C)C

Technology Process of tert-butyl N-(3-methylpyridin-4-yl)carbamate

There total 5 articles about tert-butyl N-(3-methylpyridin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-amino-3-methylpyridine (1990-90-5,953018-16-1) + di-tert-butyl dicarbonate (24424-99-5) → (3-methylpyridin-4-yl)carbamic acid tert-butyl ester (180253-65-0)

Guidance literature:

In tert-butyl alcohol; at 20 ℃;

Reference yield: 81.0%

→ (3-methylpyridin-4-yl)carbamic acid tert-butyl ester (180253-65-0)

Guidance literature:

In ethyl acetate; at 20 ℃; for 16h;

Reference yield:

4-amino-3-methylpyridine (1990-90-5,953018-16-1) → (3-methylpyridin-4-yl)carbamic acid tert-butyl ester (180253-65-0)

Guidance literature:

upstream raw materials:

N-(4-pyridyl) t-butyl carbamate

methyl iodide

4-amino-3-methylpyridine

di-tert-butyl dicarbonate

Downstream raw materials:

ethyl 1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Refernces

• 1、 -. "AUTOTAXIN INHIBITORS AND USES THEREOF". . . Retrieved 2019/12/15.
• 2、 Makida, Yusuke,Saita, Masahiro,Kuramoto, Takahiro,Ishizuka, Kentaro,Kuwano, Ryoichi. "Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes". supporting information. p. 11859 - 11862. Retrieved 2016/11/16.