5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

Base Information

Chemical Name:5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole
CAS No.:1398409-25-0
Molecular Formula:C₂₃H₂₀FN₃O₂
Molecular Weight:389.429
Hs Code.:

Synonyms:5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

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Chemical Property of 5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

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Technology Process of 5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

There total 3 articles about 5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1346229-71-7
5-(3-bromophenyl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: 1398409-25-0
5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; at 150 ℃; for 6h; Inert atmosphere;
DOI:10.1002/ardp.201200025

Reference yield:

: C₁₇H₁₆BrNO₃

: 1398409-25-0
5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 30 - 35 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 6 h / 150 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1002/ardp.201200025

Reference yield:

: 55308-52-6
ethyl 3-methoxybenzimidate

: 1398409-25-0
5-(2'-fluoro-3'-methoxybiphenyl-3-yl)-3-(3-methoxyphenyl)-1-methyl-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 6 h / 30 - 35 °C

2: dichloromethane / 4 h / 30 - 35 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 6 h / 150 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; water; 3: Suzuki coupling;
DOI:10.1002/ardp.201200025