methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

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Chemical Name:methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride
CAS No.:919988-51-5
Molecular Formula:C₅₄H₅₁F₅N₄O₁₀*ClH
Molecular Weight:1047.47
Hs Code.:

methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

Synonyms:methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

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Chemical Property of methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

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Technology Process of methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

There total 9 articles about methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 919988-50-4
methyl 4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}-3-({(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}amino)butanoate

: 919988-51-5
methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 0.75h;

Reference yield:

: 919988-45-7
methyl 4-(3-bromophenyl)-3-[(tert-butoxycarbonyl)amino]butanoate

: 919988-51-5
methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 6 h / 50 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 0 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / -25 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 0.75 h / 0 °C

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 919988-44-6
4-(3-bromophenyl)-3-[(tert-butoxycarbonyl)amino]butanoic acid

: 919988-51-5
methyl 3-[((2S)-2-amino-5-{[(benzyloxy)carbonyl]amino}pentanoyl)amino]-4-{4'-(benzyloxy)-3'-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-oxo-3-(pentafluorophenoxy)propyl]biphenyl-3-yl}butanoate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 0 - 20 °C

2.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 6 h / 50 °C

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 0 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / -25 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 0.75 h / 0 °C

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;