2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

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Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid
CAS No.:1403380-82-4
Molecular Formula:C₂₂H₂₆O₄
Molecular Weight:354.446
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

There total 6 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1403381-19-0
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetate

: 1403380-82-4
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetate; With water; potassium hydroxide; In ethanol; for 1h; Reflux;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 53663-39-1
3-methyl-2-bromobenzoic acid

: 1403380-82-4
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 3 h / Reflux

3.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 90 °C

3.2: 1 h / Reflux

4.1: perchloric acid / 2 h / -20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 85 °C

6.1: potassium hydroxide; water / ethanol / 1 h / Reflux

6.2: pH 3

With selenium(IV) oxide; thionyl chloride; perchloric acid; water; sodium carbonate; triethylamine; potassium hydroxide; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In 1,4-dioxane; ethanol; water; toluene; acetonitrile;

Reference yield:

: 944268-58-0
1-(2-bromo-3-methylphenyl)ethan-1-one

: 1403380-82-4
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-methylphenyl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 90 °C

1.2: 1 h / Reflux

2.1: perchloric acid / 2 h / -20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 85 °C

4.1: potassium hydroxide; water / ethanol / 1 h / Reflux

4.2: pH 3

With selenium(IV) oxide; perchloric acid; water; sodium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In 1,4-dioxane; ethanol; water; toluene;