1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium

Base Information

• Chemical Name: 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium
• CAS No.: 1263486-06-1
• Molecular Formula: C₁₉H₁₃ClFN₃O₂S
• Molecular Weight: 401.849
• Mol file: 1263486-06-1.mol

Synonyms:1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium

Chemical Property of 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium

There total 7 articles about 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

N-[(2-chloro-5-thiazolyl)methyl]-3-methyl-2-pyridinamine (1263089-45-7) + 1,3-bis(4-nitrophenyl) 2-(2-fluorophenyl)propanedioate (1263089-47-9) → 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium (1263486-06-1)

Guidance literature:

With 1H-imidazole; In ethyl acetate; at 72 - 77 ℃; for 2h;

Reference yield:

N-[(2-chloro-5-thiazolyl)methyl]-3-methyl-2-pyridinamine (1263089-45-7) + 1,3-bis(2,4,6-trichlorophenyl) 2-(2-fluorophenyl)propanedioate (1263089-46-8) → 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium (1263486-06-1)

Guidance literature:

In toluene; at 70 ℃; for 1h;

Reference yield:

2-fluorophenyl acetonitrile (326-62-5) → 1-[(2-chloro-5-thiazolyl)methyl]-3-(2-fluorophenyl)-2-oxido-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium (1263486-06-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium methylate / toluene / 5.25 h / 70 - 75 °C / Inert atmosphere

1.2: 10 - 15 °C

2.1: thionyl chloride / 19.75 h / 0 - 45 °C / Inert atmosphere

3.1: tetramethlyammonium chloride; sodium hydroxide; water / 10 - 32 °C

3.2: 1 h / 5 - 10 °C / pH 2

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.2: 20 °C

5.1: toluene / 1 h / 70 °C

With thionyl chloride; oxalyl dichloride; water; sodium methylate; tetramethlyammonium chloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; toluene;

upstream raw materials:

2-fluorophenyl acetonitrile

3-methylpyridin-2-ylamine

dimethyl 2-(2-fluorophenyl)malonate

2-(2-fluorophenyl)propanedioic acid